Okadaic acid is a causative agent of diarrhetic shellfish poisoning isolated from the sponge Halichondria Okadai. Okadaic Acid exhibits various activities as follows: Contractile effect on smooth muscles in Ca 2+ free solution. Non-TPA type promoting agent of carcinogenesis.

27 May 2015 Okadaic acid (OA) is a marine polyether cytotoxin that was first isolated from the marine sponge Halichondria okadai. OA is a potent inhibitor of

This test is suitable for the quantitative and/or qualitative detection of Okadaic Acid in water samples as well as shellfish samples. For shellfish samples a sample preparation is required. Okadaic acid activates the PKR pathway and induces apoptosis through PKR stimulation in MG63 osteoblast-like cells. Haneji T et al (2013) Int J Oncol 42(6) : 1904-10. PubMedID: 23591640. Inhibitory effect of a marine-sponge toxin, okadaic acid Okadaic acid is a polyether derivative of 38-carbon fatty acid, and is implicated as the causative agent of diarrhetic shellfish poisoning. It is a potent tumour promoter that is not an activator of protein kinase C, but is a powerful inhibitor of protein phosphatases-1 and -2A (PP1 and PP2A) in vitro.

Okadaic acid

Why trust us? Woah, what? Unless you live in a plac A strong acid is one that is 100 percent ionized in a solution, and a weak acid is one that doesn't ionize fully when dissolved in water. Sulfuric acid is A strong acid is one that is 100 percent ionized in a solution, and a weak acid is on Live a Healthy Lifestyle! Subscribe to our free newsletters to receive latest health news and alerts to your email inbox. Okadaic acid.

CAS 78111-17-8, is a 250 µM solution of Okadaic Acid in DMSO. Potent inhibitor of protein phosphatase 1 (IC50 = 10-15 nM) and 2A (IC50 = … (3). Okadaic acid has also been described as a non-TPA type potent tumor promoter (4).

InSolution Okadaic Acid, Prorocentrum sp. CAS 78111-17-8, is a 250 µM solution of Okadaic Acid in DMSO. Potent inhibitor of protein phosphatase 1 (IC50 = 10-15 nM) and 2A (IC50 = 0.1 nM). Sigma-Aldrich

References. 1. Cohen [Okadaic Acid] .We manufacture and distribute chemical reagents for research use only or various antibodies.

Okadaic Acid is one of the toxins associated with diarrheic shellfish poisoning ( DSP). This test is suitable for the quantitative and/or qualitative detection of Okadaic

Okadaic acid is a non-comepetitive, selective and reversible serine/threonine-specific protein phosphatases 1 (PP1), PP2A and PP3 inhibitor with IC50s of 10-15 nM, 0.5 nM and 4 nM, respectively.

This toxin potently and specifically inhibits PP-1 and PP-2A, although with different IC 50 concentrations. Despite sharing similar structure and catalytic The three main results of the study were as follows: (1) The saxitoxin-group toxins, okadaic acid and analogues, and pectenotoxins were the major phycotoxin residues found in scallops; (2) Six kinds of toxic microalgae were identified, Protoperidinium spp., Gonyaulax spp., and Alexandrium spp. were the dominant taxa; Seven types of potential Okadaic acid (or okadeic acid, CAS 78111-17-8, C 44 H 68 O 13) is produced by dinoflagelates Dinophysis sp. and Prorocentrum lima. Lipophilic okadaic acid is a potent inhibitor of protein phosphorylase phosphatase-1 and -2A in the cytosol of the mammalian cells that dephosphorylates serine and threonine.
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It is also a potent tumor promoter. It is produced by DINOFLAGELLATES and causes diarrhetic SHELLFISH POISONING. Structure : Top Interacting Genes Scientific Opinion: Marine biotoxins in shellfish - okadaic acid and analogues; EFSA’s CONTAM Panel[1] has assessed the available data and identified for OA-group toxins a level at which most consumers, even those eating a large portion of shellfish, would be unlikely to get shellfish poisoning. Okadaic acid is a polyether compound isolated from the black sponge Halichondria okadai.

Apoptosis Inducer & Phosphatase Inhibitor; induces apoptosis e.g. in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells. Buy Okadaic Acid Sodium Salt - an affordable, high quality PP1 Inhibitor from Hello Bio, a trusted supplier for life science researchers worldwide.
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31 Jan 2008 This is the first in a series of nine opinions on the various biotoxins and it addresses one group , okadaic acid (OA) and related toxins that

Okadaic acid is stable, and not readily destroyed by cooking, and can survive storage conditions. So it is for this reason that the State of Texas closed Galveston Bay for oystering. First reported in the Netherlands in 1961 (1), DSP soon became worldwide with outbreaks in Japan in the 1970s.

Okadaic acid significantly increased phosphorylation of CaMKII; indicating a major role of PP1 in CaMKII dephosphorylation. Literature in this Area Tocris offers the following scientific literature in this area to showcase our products.

Woah, what? Unless you live in a plac A strong acid is one that is 100 percent ionized in a solution, and a weak acid is one that doesn't ionize fully when dissolved in water. Sulfuric acid is A strong acid is one that is 100 percent ionized in a solution, and a weak acid is on Live a Healthy Lifestyle! Subscribe to our free newsletters to receive latest health news and alerts to your email inbox. Okadaic acid.

In higher concentrations Okadaic acid induced apoptosis (IC 50 = 0.5 µM). 1-4 Keywords: Okadaic Acid, Diarrhetic Shellfish, protein kinases (PKs), threonine-specific (PSPs), tyrosine-specific (PTPs) enzymes, OKADAIC ACID CLASS INHIBITORS, Halichondria okadai, Pandoras acanthifolium, Dinophysis, Prorocentrum Okadaic acid: an additional non-phorbol-12-tetradecanoate-13-acetate- type tumor promoter: M. Suganuma, et al.; PNAS 85, 1768 (1988); Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Dealing with heartburn and stomach acid troubles is an uncomfortable condition that nearly everyone experiences from time.